Methods of administering CRF antagonists

ABSTRACT

Substituted pyrrazoles of the formula                    
     wherein R 1 , R 2 , R 3 , X, Y, Z and A are as defined herein with reference to formula I; pyrazoles and pyzazolopyrimidines of the formula                    
     wherein R 1 , R 2 , R 3 , R 4  and A are defined herein with reference to formula VII; compounds of the formula                    
     wherein A, R 3 , R 4  and R. are as defined herein with reference to formula VIII; and pyrrolopyzimidines of the formula                    
     wherein B1 R3, R4, R5 and R6 are as defined herein, with reference to formula IX, have corticotropin-releasing factor antagonist activity and as such are of use in the treatment of a variety of stress-related disorders.

This application is a Division od Ser. No. 08/259,835, filed Jun. 15, 1994, now U.S. Pat. No. 5,646,152.

BACKGROUND OF THE INVENTION

The present invention relates to the treatment of certain illnesses by administering novel corticortropin-releasing factor (CRF) antagonists.

CRF antagonists are mentioned in U.S. Pat. Nos. 4,605,642 and 5,063,245 referring to peptides and pyrazolinones, respectively. The importance of CRF antagonists is set out in the literature, e.g. as discussed in U.S. Pat. No. 5,063,245. A recent outline of the different activities possessed by CRF antagonists is found in M. J. Owens et al., Pharm. Rev., Vol. 43, pages 425 to 473 (1991).

The CRF antagonists administered according to the invention are described in copending patent application Ser. Nos. PCT/US 93/10716, PCT/US93/01539, PCT/US93/11333, and PCT/US93/10715, all of which are incorporated herein by reference.

SUMMARY OF THE INVENTION

The present invention relates to the treatment of certain illnesses which comprises administering to a subject in need of such treatment an effective amount of a compound of the formula

and the pharmaceutically acceptable acid addition salts thereof,

wherein A is CH₂;

R₁, R₂ and R₃ are each independently linear C₁-C₅ alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl wherein the double bond is not adjacent to the N or X₁ when X₁ is oxygen or sulfur, or C₃-C₇ cycloalkyl (CH₂)n wherein n is 0, 1, 2, 3 or 4; or R₁ and R₂ when taken together with the nitrogen form a saturated four, five or six membered ring optionally condensed with benzo; and R₃ may also be (CH₂)_(q)Q₁R₁₉ wherein q is 0, 1 or 2, Q₁ is O, S, NH, N(C₁-C₆ alkyl) or a covalent bond when X₁ is not a covalent bond, and R₁₉ is hydrogen, linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl, C₃-C₈ cycloalkyl or C₃-C₆ cycloalkyl (CH₂)n wherein n is 1 to 4;

X₁ is a covalent bond, CH₂, NR wherein R is hydrogen or linear C₁-C₆ alkyl, O, or S;

Y is phenyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, benzimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, isoxazolyl, benzisoxazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, benzoxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, or piperidinyl, each of which may be substituted by one to three of any one of fluoro, chloro, bromo, or methyl, or one of trifluoromethyl; with the proviso that Y is not unsubstituted phenyl; and

wherein the B ring is phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazilyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thienyl, or indolyl, each of which may be substituted by methyl, methoxy, fluoro, chloro, bromo or iodo; or a saturated 5- or 6-membered carbocyclic ring or a partially unsaturated ring having one or two double bonds;

R₄ is hydrogen, C₁-C₆ alkyl, C₁-C₆ alkoxy, or hydroxy, fluoro, chloro, bromo, iodo, or trifluoromethyl;

R₅ is hydrogen, linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl, or (CH₂)_(o)—X₂—(CH₂)_(r)—Q₂—R₆;

R₆ is hydrogen, linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, or C₃-C₈ alkenyl;

X₂ and Q₂ are each independently O, S, NH, N(C₁-C₆ alkyl), or one of X₂ and Q may be a covalent bond;

m is 0 or 1;

o is 1 or 2;

p is 1 or 2;

r is 0, 1, or 2;

wherein R₄ and R5 are as defined above, and t and u are each independently 1 or 2;

(c) —NR₇R₈ wherein R₇ and RB are each independently hydrogen, C₁-C₆ linear alkyl, branched C₃-C₈ alkyl, C₃-C, alkenyl, (CH₂)_(v)CH₂OH, (CH₂)_(v)NR₉R₁₀, wherein v is 0 to 3, and R₉ and R₁₀ are each independently hydrogen, or linear C₁-C₆ alkyl; C₁-C₁₂ cycloalkyl, (C₃-C₁₂ cycloalkyl) (CH₂)_(n), (C₆-C₁₀ bicycloalkyl) (CH₂)_(n), wherein n is 0 to 4, benzofused C₃-C₆ cycloalkyl, C₁-C₆ hydroxyalkyl, phenyl, phenyl (C₁-C₃ alkylene), each of which may be substituted by one or two of hydroxy, fluoro, chloro, bromo, C₁-C₅ alkyl, or C₁-C₅ alkoxy; or R₇ and R₈ may be taken together with the nitrogen to form a saturated or partially unsaturated 5- to 7-membered ring which may contain one of O, S, NH or N(C₁-C₆ alkyl) and which may be substituted by C₁-C₆ alkyl, hydroxy or phenyl wherein any double bond(s) are not adjacent to any heteroatoms;

wherein B, R₄ and R₅ are as defined above, w, x, y and z are each independently 1 or 2, and W is (CH₂)_(q) wherein q is as defined above, N(C₁-C₆ alkyl), or oxygen;

wherein B, R₄, m and p are as defined above;

wherein B and R₄ are as defined above;

(g) O(CH₂)_(v)R₁₁

wherein v is 0 to 3 and R₁₁ is linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, benzimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, isoxazolyl, benzisoxazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, benzoxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, piperidinyl, or thienyl, each of which may be substituted by one or two of any one of fluoro, chloro, bromo, methyl, or trifluoromethyl;

and the pharmaceutically acceptable acid addition salts thereof, wherein

A is C═O or SO₂, or A and R₁ together with the carbons to which they are attached form pyrimidinyl or 5-pyridyl which may be substituted by R₅ which is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), SH, S(O)_(n)(C₁-C₆ alkyl) wherein n=0, 1 or 2, wherein said C₁-C₆ alkyl may be substituted by from 1 to 3 substituents R₆ which is hydroxy, amino, C₁-C₃ alkoxy, dimethylamino, diethylamino, methylamino, ethylamino, NH(C═O)CH₃, fluoro, chloro, bromo or C₁-C₃ thioalkyl;

R₁ is hydrogen, C₁-C₆ alkyl, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), wherein said C₁-C₆ alkyl may be substituted by from 1 to 3 substituents R₆ as defined above;

R₂ is hydrogen, C₁-C₆ alkyl, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), SH, S(O)_(n)(C₁-C₆ alkyl) wherein n=0, 1, or 2, cyano, hydroxy, carboxy, or amido, wherein said alkyls may be substituted by one to three of hydroxy, amino, carboxy, amido, NH(C═O)(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), (C═O)O(C₁-C₆ alkyl), C₁-C₃ alkoxy, C₁-C₃ thioalkyl, fluoro, bromo, chloro, iodo, cyano or nitro;

R₃ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, pyridinyl, tetrazolyl, or 9 to 12 membered bicycloalkyl, optionally containing one to three of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or phenylmethyl, wherein each one of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, C₁-C₆ alkyl, C₁-C₆ alkoxy, or trifluoromethyl, or one of cyano, nitro, amino, NH(C₁-C₆ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NHSO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; and

R₄ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, pyridinyl, tetrazolyl, or 3 to 8-membered cycloalkyl or 9 to 12-membered bicycloalkyl, optionally containing one to three of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or phenylmethyl, wherein each of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, trifluoromethyl, C₁-C₆ alkyl or C₁-C₆ alkoxy, or one of cyano, nitro, amino, NH(C₁-C₆ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NH₂SO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; provided that (1) R₄ is not unsubstituted phenyl; (2) when R₁ is amino, R₂ is methylthio, R₄ is 2,4,6-trichlorophenyl, and A is C=0, then R₃ is not 2-chlorophenyl; and (3) R₁ and R₂ are not both hydrogen;

and the pharmaceutically acceptable acid addition salts thereof, wherein

A is NR₁R₂, CR₁R₂R₁₁, or C(═CR₁R₁₂)R₂, NHCR₁R₂R₁₁, OCR₁R₂R₁₁, SCR₁R₂R₁₁, NHNR₁R₂, CR₂R₁₁NHR₁, CR₂R₁₁ OR₁, CR₂R₁₁SR₁ or C(O)R₂;

R₁ is hydrogen, or C₁-C₆ alkyl which may be substituted by one or two substituents R₆ independently selected from the group consisting of hydroxy, fluoro, chloro, bromo, iodo,

and said C₁-C₆ alkyl may contain one or two double or triple bonds;

R² is C₁-C₁₂ alkyl, aryl or (C₁-C₁₀ alkylene)aryl wherein said aryl is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, or benzoxazolyl; 3- to 8-membered cycloalkyl or (C₁-C₆ alkylene) cycloalkyl, wherein said cycloalkyl may contain one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄-alkyl, benzyl or C₁-C₄ alkanoyl, wherein R² may be substituted independently by from one to three of chloro, fluoro, or C₁-C₄ alkyl, or one of hydroxy, bromo, iodo, C₁-C₆ alkoxy,

and wherein said C₁-C₁₂ alkyl or C₁-C₁₀ alkylene may contain one to three double or triple bonds; or

NR₁ R₂ or CR₁R₂R₁₁ may form a 4- to 8-membered ring optionally containing one or two double bonds or one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, benzyl, or C₁-C₄ alkanoyl;

R₃ is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, iodo, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SH, S(C₁-C₄ alkyl), SO(C₁-C₄ alkyl), or SO₂(C₁-C₄ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may contain one or two double or triple bonds and may be substituted by from 1 to 3 substituents R₇ independently selected from the group consisting of hydroxy, amino, C₁-C₃ alkoxy, dimethylamino, diethylamino, methylamino, ethylamino,

fluoro, chloro or C₁-C₃ thioalkyl;

R₄ is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, iodo, C₁-C₆ alkoxy, amino, NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl) (C₁-C₂ alkyl), SO,,(C₁-C₆ alkyl), wherein n is 0, 1 or 2, cyano, hydroxy, carboxy, or amido, wherein said C₁-C₆ alkyls may be substituted by one to three of hydroxy, amino, carboxy, amido,

fluoro, bromo, chloro, iodo, cyano or nitro;

R₅ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, pyrrolopyridyl benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, piperazinyl, piperidinyl, tetrazolyl, or 3- to 8-membered cycloalkyl or 9- to 12-membered bicycloalkyl, optionally containing one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or benzyl, wherein each one of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, formyl, C₁-C₆ alkyl, C₁-C₆ alkoxy or trifluoromethyl, or one of hydroxy, iodo, cyano, nitro, amino, cyclopropyl, NH(C₁-C₄ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NHSO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁ -C₄ alkyl and C₁-C₆ alkyl may have one double or triple bond and may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; with the proviso that R₅ is not unsubstituted phenyl;

R₁₁ is hydrogen, hydroxy, fluoro, chloro, COO(C₁-C₂ alkyl), cyano, or CO(C₁-C₂ aklyl); and

R₁₂ is hydrogen or C₁-C₄ alkyl;

(a) A is not straight chain C₁-C₁₂ alkyl;

(b) R₅ is not a sugar group;

(c) when R₃ and R₄ are hydrogen and R₅ is chlorophenyl, then A is not NH—CH(CH₃)—(CH₂)₃—N(C₂H₅)₂;

(d) when R₃ and R₄ are hydrogen and A is NR₁R₂ wherein R₁ is C₃-C₇ cycloalkyl, and R₂ is C₂-C₆ alkenyl, phenyl-(C₁-C₆ alkylene) or hetero-(C₁-C₆ alkylene) wherein the hetero radical is furyl, thienyl or pyridinyl, and wherein said phenyl may be substituted by fluoro, chloro, bromo or iodo, then R₅ is not tetrahydrofuranyl or tetrahydropyranyl;

(e) when R₃ is methoxy, methylthio, or methylsulfonyl, R₄ is hydrogen, and R₅ is tetrahydrofuranyl or tetrahydropyranyl, then A is not NH(C₁-C₂alkyl), morpholinyl, hydrazino, or NHC₂H₄C₆H₅ which may be substituted by one methyl or two methoxy;

(f) when R₃ is hydrogen, C₁-C₆ alkyl, hydrazino, chloro, bromo, SH, or S (C₁-C₄ alkyl), R₄is hydrogen and R. is C₃-C₈ cycloalkyl, then A is not hydrazino, NH(C₁-C₂ alkyl) or N(C₁-C₆ alkyl) (C₁-C₁₂ alkyl);

(g) when R₃ and R₄ are hydrogen and A is NH(CH₂)_(m) COOH wherein m is 1-12, then R₅ is not phenyl substituted by one of fluoro, chloro, bromo or iodo;

(h) when R₃ is hydrogen, hydroxy, methylthio, chloro or NHbenzyl, R₄ is hydrogen, and R₅ is chlorophenyl or bromophenyl, then A is not NH(C₁-C₁₂ alkyl), NHallyl, or N(C₁-C₆ alkyl) (C₁-C₁₂ alkyl), wherein said C₁-C₁₂ alkyl may be substituted by NC₂H₅, or NH benzyl which may be substituted by one or two bromo, chloro, fluoro, NC₂H₅ phenyl or morpholinopropyl;

(i) when R₃ and R₄ are hydrogen and R₅ is nitrophenyl, then A is not NHR₂ wherein R₂ is C₁-C₁₂ alkyl which may be substituted by two hydroxy, or R₂ is phenyl or benzyl;

(j) when R₃ is chloro or O(C₁-C₆ alkyl), R₄ is hydrogen, and A is NR₁R₂ wherein R₁ and R₂ are independently hydrogen or C₁-C₆ alkyl, then R₅ is not chlorophenyl; and

(k) when R₃ is hydrogen, A is benzyl or phenethyl, and R₄ is fluoro, chloro, bromo or iodo, then R₅ is not 5′-deoxy-ribofuranosyl or 5′-amino-5′-deoxy-ribofuranosyl; or

and the pharmaceutically acceptable acid addition salts thereof, wherein

B is NR₁R₂, CR₁R₂R₁₁, C(═CR₂R₁₂)R₁, NHCR₁R₂R₁₁, OCR₁R₂R₁₁, SCR₁R₂R,, NHNR, R₂, CR₂R₁₁ NHR₁, CR₂R₁₁ OR₁, CR₂R₁₁ SR₁, or C(O)R₂;

R₁ is hydrogen, or C₁-C₆ alkyl which may be substituted by one or two substituents R₇ independently selected from the group consisting of hydroxy, fluoro, chloro, bromo, iodo,

and said C₁-C₆ alkyl may contain one or two double or triple bonds;

R₂ is C₁-C₁₂ alkyl, aryl or (C₁-C₁₀ alkylene)aryl wherein said aryl is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, pyrrolopyridyl, oxazolyl, or benzoxazolyl; 3- to 8-membered cycloalkyl or (C₁-C₆ alkylene) cycloalkyl, wherein said cycloalkyl may contain one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, benzyl or C₁-C₄ alkanoyl, wherein R₂ may be substituted independently by from one to three of chloro, fluoro, or C₁-C₄ alkyl, or one of hydroxy, bromo, iodo,

and wherein said C₁-C₁₂ alkyl or C₁-C₁₀ alkylene may contain one to three double or triple bonds; or

NR₁R₂ or CR₁R₂R₁₁, may form a saturated 3- to 8-membered ring of which the 5- to 8-membered ring may contain one or two double bonds or one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, benzyl or C₁-C₄ alkanoyl;

R₃ is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, iodo, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SH, S(C₁-C₄ alkyl), SO(C₁-C₄ alkyl), or SO₂(C₁-C₄ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may contain one double or triple bond and may be substituted by from 1 to 3 substituents R₈ independently selected from the group consisting of hydroxy, C₁-C₃ alkoxy, fluoro, chloro or C₁-C₃ thioalkyl;

R₄ is hydrogen, C₁-C₅ alkyl, fluoro, chloro, bromo, iodo, C₁-C₆ alkoxy, amino, NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₂ alkyl), SO_(n)(C₁-C₆ alkyl), wherein n is 0, 1 or 2, cyano, hydroxy, carboxy, or amido, wherein said C₁-C₆ alkyls may be substituted by one hydroxy, trifluoromethyl, amino, carboxy, amido,

fluoro, bromo, chloro, iodo, cyano or nitro;

R₅ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, pyrrolopyridyl, benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrazolyl, or 3- to 8-membered cycloalkyl or 9- to 12-membered bicycloalkyl, optionally containing one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or phenylmethyl, wherein each one of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, formyl, C₁-C₆ alkyl, C₁-C₆ alkoxy or trifluoromethyl, or one of hydroxy, iodo, cyano, nitro, amino, NH(C₁-C₄ alkyl), N(C₁-C₄)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NHSO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may be substituted by one or two of fluoro, chloro, hydroxy, C₁-C₄ alkoxy, amino, methylamino, dimethylamino or acetyl wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may contain one double or triple bond; with the proviso that R₅ is not unsubstituted phenyl;

R₆ is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, iodo, C₁-C₆ alkoxy, formyl, amino, NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₂ alkyl), SO,,(C₁-C₆ alkyl), wherein n is 0, 1 or 2, cyano, carboxy, or amido, wherein said C₁-C₆ alkyls may be substituted by one hydroxy, trifluoromethyl, amino, carboxy, amido,

fluoro, bromo, chloro, iodo, cyano or nitro;

R₁₁ is hydrogen, hydroxy, fluoro, chloro, COO(C₁-C₂ alkyl), cyano, or CO(C₁-C₂ alkyl); and

R₁₂ is hydrogen or C₁-C₄ alkyl; with the proviso that (1) B is not straight chain C₁-C₁₂ alkyl, (2) when R₅ is unsubstituted cycloakyl, R₃ and R₄ are hydrogen, and R₆ is hydrogen or methyl, then B is not NHR₂ wherein R₂ is benzyl or thienylmethyl, and (3) when R₅ is p-bromophenyl, and R₃, R₄ and R. are methyl, then B not methylamino or hydroxyethylamino, said disorders being selected from group consisting of panic, phobias including agoraphobia, social phobia, and simple phobia, obsessive-compulsive disorder, post-traumatic stress disorder, single episode depression, recurrent depression, dysthymia, bipolar disorders, cyclothymia, mood disorders, postpartum depression, child abuse induced depression, sleep disorders, stress induced pain perception including fibromyalgia, fibromyalgic sleep disorders, rheumatoid arthritis, osteroarthritis, psoriasis, euthyroid sick syndrome, syndrome of inappropriate antidiarrhetic syndrome hormone (ADH), bulimia nervosa eating disorder, and obesity.

More specific compounds of formula I of the invention include those wherein Y is phenyl substituted by three substituents one each at positions 2, 4 and 6, e.g. 2,4,6-trichlorophenyl, 2,6-dichloro-4-trifluoromethylphenyl, or 2,6-dichloro-4-fluorophenyl. Other more specific compounds of formula I include those wherein XR₃ is ethyl or methylthio, those wherein R₁ and R₂ are each methyl, and those wherein Z is NR₇R. and R₇is phenyl or phenyl substituted by one of fluoro, chloro, nitro, methyl or methoxy and R₈ is as defined above, preferably, (CH₂)₃OH, CH₂CH₂OH or methyl.

Preferred compounds of formula I are those wherein Z is 1,2,3,4-tetrahydroisoquinolin-2-yl substituted by R₅ which is —(CH₂)_(o)—X₂-(CH₂)_(r)—Q₂—R₆, more specifically R₅ is —(CH₂)_(k)OH wherein k is an integer of 1 to 4, or —CH₂OCH₂CH₂OR₆. Other preferred compounds of formula I are those wherein Z is 1,2,3,4-tetrahydroquinolin-2-yl wherein R₅ is substituted at position 3, and the absolute configuration at the 3 position is either S or R or R,S.

Preferred compounds of the formula I include those wherein Z is as defined in above subparagraph (h); and those wherein Z is as defined in (h), A is linked to position 1, F, G, H, I, J and K are each carbon, and R₁₄ is methoxy, ethoxy, isopropoxy, or cyclopropylmethoxy at position 2.

Other preferred compounds of formula I are those wherein Z is as defined in above subparagraph (h), A is linked to position 1, K is nitrogen, F, G, H, I, and J are each carbon, and R₁₄ is —X₂—(CH₂)_(r)Q₂R₆ at position 2; those wherein Z is as defined in (h), A is linked to position 1, K is nitrogen, F, G, H, I, and J are each carbon, and R₁₄ is methoxy, ethoxy, isopropoxy, or cyclopropylmethoxy at position 2; and those wherein Z is as defined in (h), A is at position 1, and R₁₄ is ethoxy, isopropoxy or cyclopropylmethoxy at position 2. In these preferred compounds of formula I wherein Z is as defined in (h), R₁₂ and R₁₃ are preferably hydrogen.

Other preferred compounds of formula I are those wherein Z is as defined in subparagraph (a), B is phenyl, p and m are each 1, and R₅ is CH₂OCH₃.

Preferred compounds of formula I include those wherein Z is

wherein B is phenyl, m is 0, and p is 1.

More specific compounds of the formula VII include those wherein R₃ is phenyl substituted independently with one or two of fluoro, chloro, bromo, methyl, trifluoromethyl, nitro, C₁-C alkyl, C₁-C₆ alkyloxy, SO₂NH₂, SO₂NH(C₁-C₆ alkyl), SO₂N(C₁-C₆ alkyl)₂, or R₃ is primary, secondary or tertiary alkyl of from 4-9 carbon atoms wherein said C₄-C₉ alkyl may contain from one to two double or triple bonds and may be substituted by from 1 to 3 substituents R₆ which is hydroxy, amino, C₁-C₃ alkoxy, dimethylamino, diethylamino, methylamino, ethylamino, NH(C═O)CH₃, fluoro, chloro, bromo, or C₁-C₃ thioalkyl.

More specific compounds of the formula VII are those wherein A is C═O, those wherein R₁ is amino, methylamino or dimethylamino; those wherein R₂ is ethyl or ethylthio and those wherein R₄ is 2,4,6-trichlorophenyl, 2,4,6-trimethylphenyl, 2,6-dichloro-4-trifluoromethylphenyl or 4-bromo-2,6-dimethylphenyl.

More specific compounds of formula VII further include those wherein R₃ is phenyl which may be substituted at positions 2 or 5 with one or two of methyl, C₂-C₆ straight-chain or branched alkyl, trifluoromethyl, fluoro, chloro, bromo or nitro, those wherein A and R₁ together form a pyrimidine ring, such that the bicyclic structure formed is pyrazolo[3,4-d]pyrimidine, and R₅ is substituted at the 6 position; and those wherein R₃ is phenyl substituted independently with one or two of fluoro, chloro, bromo, methyl, trifluoromethyl, nitro, C₁-C₆ alkyl, C₁-C₆ alkyloxy, SO₂NH₂, SO₂NH(C₁-C₆ alkyl), or SO₂N(C₁-C₆alkyl)₂, R₄ is 2,4,6-trichlorophenyl, 2,4,6-trimethylphenyl, 2,6-dichloro-4-trifluoromethylphenyl or 4-bromo-2,6-dimethylphenyl, and R₂ is methylthio, methyl or ethyl.

More specific compounds of formula VII also include those wherein R₃ is phenyl substituted independently with one or two of fluoro, chloro, bromo, methyl, trifluoromethyl, nitro, C₁-C₆ alkyl, C₁-C₆ alkyloxy, SO₂NH₂, SO₂NH(C₁-C₆ alkyl), SO₂N(C₁-C₆ alkyl)₂, or R₃ is primary, secondary or tertiary alkyl of from 4-9 carbon atoms wherein said C₄-C₆ alkyl may contain from one to two double or triple bonds and may be substituted by from 1 to 3 substituents R₆ which is hydroxy, amino, C₁-C₃ alkoxy, dimethylamino, diethylamino, methylamino, ethylamino, NH(C═O)CH₃, fluoro, chloro, bromo or C₁-C₃ thioalkyl; R₄ is 2,4,6-trichlorophenyl, 2,4,6-trimethylphenyl, 2,6-dichloro-4-trifluoromethylphenyl or 4-bromo-2,6-dimethylphenyl; R₁ is amino, methylamino or dimethylamino; and R₂ is methylthio or ethyl.

More specific compounds of the formula VII are those wherein A is NR₁R₂, NHCHR₁R₂, or OCHR₁R₂, wherein R₁ is C₁-C₆ alkyl, which may be substituted by one of hydroxy, fluoro or C₁-C₂ alkoxy, and may contain one double or triple bond, and R₂ is benzyl or C₁-C₅ alkyl which may contain one double or triple bond, wherein said C₁-C₆ alkyl or the phenyl in said benzyl may be substituted by fluoro, C₁-C₆ alkyl, or C₁-C₆ alkoxy; and those wherein A is CR₁R₂R₁₁ wherein R₁ is C₁-C₆ alkyl which may be substituted by one C₁-C₆ alkoxy or hydroxy, R₂ is benzyl or C₁-C₆ alkyl wherein said C₁-C₆ alkyl or the phenyl in said benzyl may be substituted by one C₁-C₆ alkyl, C₁-C₆ alkoxy, fluoro, chloro or bromo, and R₁₁ is hydrogen or fluoro.

More specific compounds of the formula VII include those wherein R₂ is (C₁-C₄ alkylene)aryl wherein said aryl is phenyl, thienyl, benzofuranyl, furanyl, benzothienyl, thiazolyl, pyridyl or benzothiazolyl.

More specific compounds of the formula VII further include those wherein R₂ is benzyl para-substituted by one of ethyl, t-butyl, methoxy, trifluoromethyl, nitro, fluoro chloro, or methyl.

Other more specific compounds of the formula VII include those wherein R₂ is attached through a methylene or ethylene bridge to quinolyl, pyrrolyl, pyrrolidinyl, pyridyl, tetrahydropyranyl, cyclopropyl, piperidinyl, or benzyl-piperidinyl.

More specific compounds VII further include those wherein R₁ or R₂ is C₁-C₆ alkyl which may be substituted by one of hydroxy, methoxy, ethoxy, chloro, fluoro, OC(O)CH₃, OC(O)NHCH₃, or C(O)NH₂.

Other more specific compounds VII include those wherein R₂ is C₁-C₆ alkyl substituted by two of methoxy or ethoxy, or one of COOC₂H₅, methylthio, or phenyl.

Other more specific compounds VII include those wherein A is NR₁R₂ or CHR₁R₂ in which R₁ and R₂ are taken together with N or CH to form a 5- or 6-membered ring having one more nitrogen, sulfur, and/or one oxygen, e.g. pyrrolidinyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, pyridyl, pyrazinyl or pyrimidyl.

Other more specific compounds VII includes those wherein A is NHCHR₁R₂ or OCHR₁R₂ in which CHR₁R₂ is a 5- or 6-membered ring which may contain one oxygen or sulfur, e.g. tetrahydrofuranyl, tetrahydrothiafuranyl and cyclopentanyl.

Preferred compounds of the formula IX of the invention are those wherein B is NR₁R₂, NHCHR₁R₂, or OCHR₁R₂, wherein R₁ is C₁-C₆ alkyl, which may be substituted by one of hydroxy, fluoro or C₁-C₂ alkoxy, and may contain one double or triple bond; those wherein R₂ is benzyl or C₁-C₆ alkyl which may contain one double or triple bond, wherein said C₁-C₆ alkyl or the phenyl in said benzyl may be substituted by fluoro, C₁-C₆ alkyl, or C₁-C₆ alkoxy; those wherein R₃ is methyl, ethyl, fluoro, chloro or methoxy; those wherein R₄ and R₆ are independently hydrogen, methyl, or ethyl; and those wherein R₅ is phenyl substituted by two or three substituents, said substituent being independently fluoro, chloro, bromo, iodo, C₁-C₄ alkoxy, trifluoromethyl, C₁-C₆ alkyl which may be substituted by one of hydroxy, C₁-C₄ alkoxy or fluoro and may have one double or triple bond, —(C₁-C₄ alkylene)O(C₁-C₂ alkyl), C₁-C₃ hydroxyalkyl, hydroxy, formyl, COO(C₁-C₂ alkyl), —(C₁-C₂ alkylene)amino, or —C(O)(C₁-C₄ alkyl).

In specific methods of the invention, said compound is

2-{1-[1-(2,6-dichloro-4-tirfluoromethylphenyl)-5-dimethylamino-3-ethyl-1H-pyrazol-4-ylmethyl]-napthalen-2-yloxy}-ethanol;

enantiomeric [4-(3-methoxymethyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-5-methylsulfanyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylaminederivedfrom(+)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline;

enantiomeric [2-(2,6-dichloro-4-trifluoromethylphenyl)4-(3-ethoxymethyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-5-ethyl-2H-pyrazol-3-yl]-dimethylamine derived from (+)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline;

[2-(2,6-dichloro-44rifluoromethylphenyl)-5-ethyl-6(7-methoxyquinolin-8ylmethyl)-2H-pyrazol-3-yl]-dimethylamine;

[2-(2,6-dichloro-4-trifluoromethylphenyl)4)2-ethoxy-napthalen-1-ylmethyl)-5-ethyl-2H-pyrazol-3-yl]-dimethylamine;

[4-(2-ethoxynapthalen-1-ylmethyl)-5-ethyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylamine;

[4-(7-methoxyquinolin-8-ylmethyl)-5-methylsulfanyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylamine;

2-{1-[5-dimethlamino-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazol-4-ylmethyl]-napthalen-2-yloxy}-ethanol;

enantiomeric [2-(2,6-dichloro-4-trifluoromethlphenyl)-5-ethyl-4-(3-methoxymethyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2H-pyrazol-3-yl]-dimethylamine derived from (+)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline;

[4-(2-cyclopropylmethoxynapthalen-1-ylmethyl)-5-methylsulfanyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylamine.

[5amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dimethylphenyl)methanone,

[5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-bis-trifluoromethylphenyl)methanone,

[5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(5-isopropyl-2-methylphenyl)methanone,

[5-amino-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolyl]-(5-isopropyl-2-methylphenyl)methanone, or

[5-amino-1-(4bromo-2,6-dimethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dibromophenyl)methanone.

[5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-l]-(2,5-dimethylphenyl)methanone,

[5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-bis-trifluoromethylphenyl)methanone,

[5-amino-1-(2,6-dichloro-4-trfluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(⁵⁻isopropyl-2-methylphenyl)methanone,

[5-amino-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazol-4-yl]-(5-isopropyl-2-methylphenyl)methanone, or

[5-amino-1-(4-bromo-2,6-dimethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dibromophenyl)methanone;

3-{(4-methyl-benzyl)-[3,6-dimethyl-1-(2,4,6-trimethylphenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amino}-propan-1-ol;

diethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

2-{butyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amino}-ethanol;

dibutyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl}-amine;

butyl-ethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amine;

butyl-ethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

butyl-cyclopropylmethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

di-1-propyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

diallyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

butyl-ethyl-[6-chloro-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amine;

butyl-ethyl-[6-methoxy-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

propyl-ethyl-[3,6-dimethyl-1-(2,4,6-trimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine;

4-(1-ethyl-propyl)-6-methyl-3-methylsulfanyl-1-(2,4,6-trimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine.

n-butyl-thyl-[2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl]amine;

di-n-propyl-[2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl]amine;

ethyl-n-propyl-[2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-l]amine;

diethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]imidin-4-yl]amine;

n-butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl]amine;

2-{N-n-butyl-N-[2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-ethanol;

4-(1-ethyl-propyl)-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidine;

n-butyl-ethyl-[2,5-dimethyl-7-(2,4-dimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl]amine;

2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidyl-4-yl]-(1-ethyl-propyl)amine; or

2-[7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo [2,3-d] pyrimidin-4-ylamino]-butan-1-ol.

DETAILED DESCRIPTION OF THE INVENTION

Whenever reference herein is made to groups (CH₂)_(q)Q₁ R₁₉ and (CH₂)₀—X₂—CH₂)_(r)—Q₂—R₆, then X₁ and Q₁, and X₂ and Q₂, respectively, are not both a heteroatom when q or r, respectively, is 1.

Whenever one of the substituents, e.g. Y or R₁ in formula 1, is a heterocyclic group, the attachment of the group is through a carbon atom.

Whenever reference is made herein to alkyl, a straight and branched chain alkyl of one to six carbon atoms is included, such as methyl, ethyl, isopropyl or hexyl.

Whenever reference is made herein to C₁-C₆ alkyl, in the definition of R₅ and R₁ formula VII, this includes unsaturated C₂-C₆ alkyl, such as C₂-C₆ alkyl having one double or triple bond, C₃-C₆ alkyl having two double bonds, and C₄-C₆ alkyl having two triple bonds.

Whenever reference is made herein to 3- to 8-membered cycloalkyl or 9- to 12-membered bicycloalkyl containing one to three of O, S or N—Z, it is understood that the oxygen and sulfur ring atoms are not adjacent to each other. The three membered cycloalkyl has just one O, S or N—Z. An example of a six membered cycloalkyl having O and N is morpholinyl.

Whenever reference is made herein to C₁-C₄ alkyl or C₁-C₆ alkyl which “may contain one or two double or triple bonds” in the definitions of R₁, R₂ and R₃, it is understood that at least two carbons are present in the alkyl for one double or triple bond, and at least four carbons for two double and triple bonds.

Whenever an alkoxy group, e.g. in the definitions of R₁ and R₂ in formula VIII, may have a double or triple bond, it is understood that such double or triple bond is not directly attached to the oxygen.

The compounds of formulae I, VII, VIII and IX, their pharmaceutically acceptable salts, and their preparation are described in, respectively, patent applications PCT/US93/10716, PCT/US93/10539, PCT/US93/11333, and PCT/US93/10715. The compounds of formulae I, VII, VIII and IX, and their pharmaceutically acceptable salts are designated hereafter as “the active compound”. It is noted that the active compounds are described above substantially in accordance with the respective patent applications.

The acid addition salts are prepared in a conventional manner by treating a solution or suspension of the free base of the active compound with one chemical equivalent of a pharmaceutically acceptable acid. Conventional concentration or crystallization techniques are employed in isolating the salts. Illustrative of suitable acids are acetic, lactic, succinic, maleic, tartaric, citric, gluconic, ascorbic, benzoic, cinnamic, fumaric, sulfuric, phosphoric, hydrochloric, hydrobromic, hydroiodic, sulfamic, sulfonic acids such as methanesulfonic, benzene sulfonic, p-toluenesulfonic, and related acids.

The active compounds may be administered alone or in combination with pharmaceutically acceptable carriers, in either single or multiple doses. Suitable pharmaceutical carriers include inert solid diluents or fillers, sterile aqueous solution and various organic solvents. The pharmaceutical compositions formed by combining the active compounds and the pharmaceutically acceptable carriers are then readily administered in a variety of dosage forms such as tablets, powders, lozenges, syrups, injectable solutions and the like. These pharmaceutical compositions can, if desired, contain additional ingredients such as flavorings, binders, excipients and the like. Thus, for purposes of oral administration, tablets containing various excipients such as sodium citrate, calcium carbonate and calcium phosphate may be employed along with various disintegrants such as starch, alginic acid and certain complex silicates, together with binding agents such as polyvinylpyrrolidone, sucrose, gelatin and acacia. Additionally, lubricating agents such as magnesium stearate, sodium lauryl sulfate and talc are often useful for tabletting purposes. Solid compositions of a similar type may also be employed as fillers in soft and hard filled gelatin capsules. Preferred materials for this include lactose or milk sugar and high molecular weight polyethylene glycols. When aqueous suspensions or elixirs are desired for oral administration, the essential active ingredient therein may be combined with various sweetening or flavoring agents, coloring matter or dyes and, if desired, emulsifying or suspending agents, together with diluents such as water, ethanol, propylene glycol, glycerin and combinations thereof.

For parenteral administration, solutions of the active compound in sesame or peanut oil, aqueous propylene glycol, or in sterile aqueous solution may be employed. Such aqueous solutions should be suitably buffered if necessary and the liquid diluent first rendered isotonic with sufficient saline or glucose. These particular aqueous solutions are especially suitable for intravenous, intramuscular, subcutaneous and intraperitoneal administration. The sterile aqueous media employed are all readily available by standard techniques known to those skilled in the art.

The effective dosage for the active compound depends on the intended route of administration and other factors such as age and weight of the patient, as generally known to a physician. The dosage also depends on the illness to be treated. The daily dosage will generally range from about 0.1 to 50 mg/kg of the body weight of the patient to be treated. The daily dosage may be given in a single dose or up to three divided doses.

The methods for testing the active compounds for their CRF antagonist activity are as described in Endocrinology, 116, 1653-1659 (1985) and Peptides 10, 179-188 (1989) which determine the binding affinity of a test compound for a CRF receptor. The binding affinities for the active compounds, expressed as IC₅₀ values, generally range from about 0.2 namomolar to about 10 micromolar. 

What is claimed is:
 1. A method for the treatment of certain disorders, which comprises administering to a subject in need of such treatment an effective amount of a compound of the formula

or a pharmaceutically acceptable acid addition salt thereof, wherein A is CH₂; R₁, R₂ and R₃ are each independently linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl wherein the double bond is not adjacent to the N or X₁ when X₁ is oxygen or sulfur, or C₃-C₇ cycloalkyl (CH₂)_(n) wherein n is 0, 1, 2, 3 or 4; or R₁ and R₂ when taken together with the nitrogen form a saturated four, five or six membered ring optionally condensed with benzo; and R₃ may also be (CH₂)_(q)Q₁R₁₉ wherein q is 0, 1 or 2, Q₁ is O, S, NH, N(C₁-C₆ alkyl) or a covalent bond when X₁ is not a covalent bond, and R₁₉ is hydrogen, linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl, C₃-C₈ cycloalkyl or C₃-C₆ cycloalkyl (CH₂), wherein n is 1 to 4; X₁ is a covalent bond, CH₂, NR wherein R is hydrogen or linear C₁-C₆ alkyl, O, or S; Y is phenyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, benzimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, isoxazolyl, benzisoxazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, benzoxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, or piperidinyl, each of which may be substituted by one to three of any one of fluoro, chloro, bromo, or methyl, or one of trifluoromethyl; with the proviso that Y is not unsubstituted phenyl; and

wherein the B ring is phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazilyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thienyl, or indolyl, each of which may be substituted by methyl, methoxy, fluoro, chloro, bromo or iodo; or a saturated 5- or 6-membered carbocyclic ring or a partially unsaturated ring having one or two double bonds; R₄ is hydrogen, C₁-C₆ alkyl, C₁-C₆ alkoxy, or hydroxy, fluoro, chloro, bromo, iodo, or trifluoromethyl; R₅ is hydrogen, linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl, or (CH₂)_(o)—X₂—(CH₂)_(r)—Q₂—R₆; R₆ is hydrogen, linear C₁-C₆ alkyl, branched C₃-C₈ alkyl, or C₃-C₈ alkenyl; X₂ and Q₂ are each independently O, S, NH, N(C₁-C₆ alkyl), or one of X₂ and Q may be a covalent bond; m is 0 or 1; o is 1 or 2; p is 1 or 2; r is 0, 1, or 2;

wherein R₄ and R₅ are as defined above, and t and u are each independently 1 or 2; (c) —NR₇R₈ wherein R₇ and R8 are each independently hydrogen, C₁-C₆ linear alkyl, branched C₃-C₈ alkyl, C₃-C₈ alkenyl, (CH₂)_(v)CH₂OH, (CH₂)_(v)NR₉R₁₀, wherein v is 0 to 3, and R₉ and R₁₀ are each independently hydrogen, or linear C₁-C₆ alkyl; C₁-C₁₂ cycloalkyl, (C₃-C₁₂ cycloalkyl) (CH₂)_(n), (C₆-C₁₀ bicycloalkyl) (CH₂)_(n), wherein n is 0 to 4, benzofused C₃-C₆ cycloalkyl, C₁-C₆ hydroxyalkyl, phenyl, phenyl (C₁-C₃ alkylene), each of which may be substituted by one or two of hydroxy, fluoro, chloro, bromo, C₁-C₅ alkyl, or C₁-C₅ alkoxy; or R₇ and R₈ may be taken together with the nitrogen to form a saturated or partially unsaturated 5- to 7-membered ring which may contain one of O, S, NH or N(C₁-C₆ alkyl) and which may be substituted by C₁-C₆ alkyl, hydroxy or phenyl wherein any double bond(s) are not adjacent to any heteroatoms;

wherein B, R₄, m and p are as defined above;

wherein B and R4 are as defined above; (g) O(CH₂)_(v)R₁₁ wherein v is 0 to 3 and R₁₁ is linear C₁ -C₆ alkyl, branched C₃-C₈ alkyl, phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, benzimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, isoxazolyl, benzisoxazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, benzoxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, piperidinyl, or thienyl, each of which may be substituted by one or two of any one of fluoro, chloro, bromo, methyl, or trifluoromethyl;

or a pharmaceutically acceptable acid addition salt thereof, wherein A is C═O or SO₂, or A and R₁ together with the carbons to which they are attached form pyrimidinyl or 5-pyridyl which may be substituted by R₅ which is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), SH, S(O)_(n)(C₁-C₆ alkyl) wherein n 0, 1 or 2, wherein said C₁-C₆ alkyl may be substituted by from 1 to 3 substituents R₆ which is hydroxy, amino, C₁-C₃ alkoxy, dimethylamino, diethylamino, methylamino, ethylamino, NH(C═O)CH₃, fluoro, chloro, bromo or C₁-C₃ thioalkyl; R₁ is hydrogen, C₁-C₆ alkyl, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), wherein said C₁-C₆ alkyl may be substituted by from 1 to 3 substituents R₆ as defined above; R₂ is hydrogen, C₁-C₆ alkyl, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), SH, S(O)_(n)(C₁-C₆ alkyl) wherein n=0, 1, or 2, cyano, hydroxy, carboxy, or amido, wherein said alkyls may be substituted by one to three of hydroxy, amino, carboxy, amido, NH(C═O)(C₁-C₆ alkyl), N(C₁-C₆ alkyl)(C₁-C₆ alkyl), (C═O)O(C₁-C₆ alkyl), C₁-C₃ alkoxy, C₁-C₃ thioalkyl, fluoro, bromo, chloro, iodo, cyano or nitro; R₃ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, pyridinyl, tetrazolyl, or 9to 12 membered bicycloalkyl, optionally containing one to three of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or phenylmethyl, wherein each one of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, C₁-C₆ alkyl, C₁-C₆ alkoxy, or trifluoromethyl, or one of cyano, nitro, amino, NH(C₁-C₆ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NHSO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; and R₄ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, pyridinyl, tetrazolyl, or 3 to 8-membered cycloalkyl or 9 to 12-membered bicycloalkyl, optionally containing one to three of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or phenylmethyl, wherein each of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, trifluoromethyl, C₁-C₆ alkyl or C₁-C₆ alkoxy, or one of cyano, nitro, amino, NH(C₁-C₆ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NH₂SO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; provided that (1) R₄ is not unsubstituted phenyl; (2) when R₁ is amino, R₂ is methylthio, R₄ is 2,4,6-trichlorophenyl, and A is C═O, then R₃ is not 2-chlorophenyl; and (3) R₁ and R₂ are not both hydrogen; or

or a pharmaceutically acceptable acid addition salt thereof, wherein A is NR₁R₂, CR₁R₂R₁₁, or C(═CR₁R₁₂)R₂, NHCR₁R₂R₁₁, OCR₁R₂R₁₁, SCR₁R₂R₁₁, NHNR, R₂, CR₂R₁₁ NHR₁, CR₂R₁₁ OR₁, CR₂R₁₁SR₁ or C(O)R₂; R₁ is hydrogen, or C₁-C₆ alkyl which may be substituted by one or two substituents R₆ independently selected from the group consisting of hydroxy, fluoro, chloro, bromo, iodo, C₁-C₆ alkoxy, —OC(O)(C₁-C₆ alkyl), —OC(O)N(C₁-C₄ alkyl)(C₁-C₂ alkyl),amino, NH(C₁-C₄ alkyl), N(C₁-C₂ alkyl)(C₁-C₄ alkyl), S(C₁-C₆ alkyl), OC(O)NH(C₁-C₄ alkyl), N(C₁-C₂ alkyl)C(O)(C₁-C₄ alkyl), —NHC(O)(C₁-C₄ alkyl), COOH, —C(O)O(C₁-C₄ alkyl), —C(O)NH(C₁-C₄ alkyl), —C(O)N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SH, CN, NO₂, SO(C₁-C₄ alkyl), SO₂(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), and said C₁-C₆ alkyl may contain one or two double or triple bonds; R² is C₁-C₁₂ alkyl, aryl or (C₁-C₁₀ alkylene)aryl wherein said aryl is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, or benzoxazolyl; 3- to 8-membered cycloalkyl or (C₁-C₆ alkylene) cycloalkyl, wherein said cycloalkyl may contain one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, benzyl or C₁-C₄ alkanoyl, wherein R² may be substituted independently by from one to three of chloro, fluoro, or C₁-C₄ alkyl, or one of hydroxy, bromo, iodo, C₁-C₆ alkoxy, —OC(O)(C₁-C₆ alkyl), O—C—N(C₁-C₄ alkyl)(C₁-C₂ alkyl), S(C₁-C₆ alkyl), NH₂, NH(C₁-C₂ alkyl), N(C₁-C₂ alkyl) (C₁-C₄ alkyl), N(C₁-C₄ alkyl)—C(O)(C₁-C₄ alkyl), NHC(O)(C₁-C₄ alkyl), COOH, C(O)O(C₁-C₄ alkyl), C(O)NH(C₁-C₄ alkyl), C(O)N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SH, CN, NO₂, SO(C₁-C₄ alkyl), SO₂(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), and wherein said C₁-C₁₂ alkyl or C₁-C₁₀ alkylene may contain one to three double or triple bonds; or NR₁ R₂ or CR, R₂R₁₁ may form a 4- to 8-membered ring optionally containing one or two double bonds or one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, benzyl, or C₁-C₄ alkanoyl; R₃ is hydrogen, C₁-CC alkyl, fluoro, chloro, bromo, iodo, hydroxy, amino, O(C₁-C₆ alkyl), NH(C₁-CC alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SH, S(C₁-C₄ alkyl), SO(C₁-C₄ alkyl), or SO₂(C₁-C₄ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may contain one or two double or triple bonds and may be substituted by from 1 to 3 substituents R₇ independently selected from the group consisting of hydroxy, amino, C₁-C₃ alkoxy, dimethylamino, diethylamino, methylamino, ethylamino, NHC(O)CH₃, fluoro, chloro or C₁-C₃ thioalkyl; R₄ is hydrogen, C₁-C₆ alkyl, fluoro, chloro, bromo, iodo, C₁-C₆ alkoxy, amino, NH(C₁-C₆ alkyl), N(C₁-C₆ alkyl) (C₁-C₂ alkyl), SO,(C₁-C₆ alkyl), wherein n is 0, 1 or 2, cyano, hydroxy, carboxy, or amido, wherein said C₁-C₆ alkyls may be substituted by one to three of hydroxy, amino, carboxy, amido, NHC(O)(C₁-C₄ alkyl), NH(C₁-C₄ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), —C(O)O(C₁-C₄ alkyl), C₁-C₃ alkoxy, C₁-C₃ thioalkyl, fluoro, bromo, chloro, iodo, cyano or nitro; R₅ is phenyl, naphthyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, thiazolyl, isoxazolyl, benzisoxazolyl, benzimidazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, pyrrolopyridyl benzoxazolyl, oxazolyl, pyrrolidinyl, thiazolidinyl, piperazinyl, piperidinyl, tetrazolyl, or 3- to 8-membered cycloalkyl or 9- to 12-membered bicycloalkyl, optionally containing one or two of O, S or N—Z wherein Z is hydrogen, C₁-C₄ alkyl, C₁-C₄ alkanoyl, phenyl or benzyl, wherein each one of the above groups may be substituted independently by from one to three of fluoro, chloro, bromo, formyl, C₁-C₆ alkyl, C₁-C₆ alkoxy or trifluoromethyl, or one of hydroxy, iodo, cyano, nitro, amino, cyclopropyl, NH(C₁-C₄ alkyl), N(C₁-C₄ alkyl)(C₁-C₂ alkyl), COO(C₁-C₄ alkyl), CO(C₁-C₄ alkyl), SO₂NH(C₁-C₄ alkyl), SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl), SO₂NH₂, NHSO₂(C₁-C₄ alkyl), S(C₁-C₆ alkyl), SO₂(C₁-C₆ alkyl), wherein said C₁-C₄ alkyl and C₁-C₆ alkyl may have one double or triple bond and may be substituted by one or two of fluoro, chloro, hydroxy, amino, methylamino, dimethylamino or acetyl; with the proviso that R₅ is not unsubstituted phenyl; R₁₁ is hydrogen, hydroxy, fluoro, chloro, COO(C₁-C₂ alkyl), cyano, or CO(C₁-C₂ aklyl); and R₁₂ is hydrogen or C₁-C₄ alkyl; (a) A is not straight chain C₁-C₁₂ alkyl; (b) R₅ is not a sugar group; (c) when R₃ and R₄ are hydrogen and R. is chlorophenyl, then A is not NH—CH(CH₃)—(CH₂)₃—N(C₂H₅)₂; (d) when R₃ and R₄ are hydrogen and A is NR₁R₂ wherein R, is C₃-C₇ cycloalkyl, and R₂ is C₂-C, alkenyl, phenyl-(C₁-C₆ alkylene) or hetero-(C₁-C₆ alkylene) wherein the hetero radical is furyl, thienyl or pyridinyl, and wherein said phenyl may be substituted by fluoro, chloro, bromo or iodo, then R₅ is not tetrahydrofuranyl or tetrahydropyranyl; (e) when R₃ is methoxy, methylthio, or methylsulfonyl, R₄ is hydrogen, and R₅ is tetrahydrofuranyl or tetrahydropyranyl, then A is not NH(C₁-C₂alkyl), morpholinyl, hydrazino, or NHC₂H₄C₆H₅ which may be substituted by one methyl or two methoxy; (f) when R₃ is hydrogen, C₁-C₆ alkyl, hydrazino, chloro, bromo, SH, or S (C₁-C₄ alkyl), R₄is hydrogen and R₅ is C₃-C₈ cycloalkyl, then A is not hydrazino, NH(C₁-C₂ alkyl) or N(C₁-C₆ alkyl) (C₁-C₁₂ alkyl); (g) when R₃ and R₄ are hydrogen and A is NH(CH₂),, COOH wherein m is 1-12, then R₅ is not phenyl substituted by one of fluoro, chloro, bromo or iodo; (h) when R₃ is hydrogen, hydroxy, methylthio, chloro or NHbenzyl, R₄ is hydrogen, and R₅ is chlorophenyl or bromophenyl, then A is not NH(C₁-C₁₂ alkyl), NHallyl, or N(C₁-C₆ alkyl) (C₁-C₁₂ alkyl), wherein said C₁-C₁₂ alkyl may be substituted by NC₂H₅, or NH benzyl which may be substituted by one or two bromo, chloro, fluoro, NC₂H₅ phenyl or morpholinopropyl; (i) when R₃ and R₄ are hydrogen and R₅ is nitrophenyl, then A is not NHR₂ wherein R₂ is C₁-C₁₂ alkyl which may be substituted by two hydroxy, or R₂ is phenyl or benzyl; (j) when R₃ is chloro or O(C₁-C₆ alkyl), R₄ is hydrogen, and A is NHR₂ wherein R₂ and R₂ are independently hydrogen or C₁-C₆ alkyl, then R₅ is not chlorophenyl; and (k) when R₃ is hydrogen, A is benzyl or phenethyl, and R₄is fluoro, chloro, bromo or iodo, then R₅ is not 5′-deoxy-ribofuranosyl or 5′-amino-5′-deoxy-ribofuranosyl; phobias obsessive-compulsive disorder, post-traumatic stress disorder, single episode depression, recurrent depression, dysthymia, bipolar disorders, cyclothymia, mood disorders, postpartum depression, child abuse induced depression, sleep disorders, stress induced pain perception fibromyalgic sleep disorders, rheumatoid arthritis, osteroarthritis, psoriasis, euthyroid sick syndrome, syndrome of inappropriate antidiarrhetic syndrome hormone (ADH), bulimia nervosa eating disorder, and obesity.
 2. A method according to claim 1, wherein said compound is 2-{1-[1-(2,6-dichloro-4-tirfluoromethylphenyl)-5dimethylamino-ethyl-1H-pyrazol-4-ylmethyl]-napthalen-2-yloxy}-ethanol; enantiomeric [4-(3-methoxymethyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-5-methylsulfanyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-y-]-dimethylamine derived from (+)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; enantiomeric [2-(2,6-dichloro-4-trifluoromethylphenyl)4-(3-ethoxymethyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-5-ethyl-2H-pyrazol-3-yl]-dimethylamine derived from (+)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; [2-(22,6-dichloro-4-trfluoromethylphenyl)-5-ethyl-2(7-methoxyquinolin-ylmethyl)-2H-pyrazol-3-yl]-dimethylamine; [2-(2,6-dichloro-4-trifluoromethylphenyl)-4-)2-ethoxy-napthalen-1-ylmethyl)-ethyl-2H-pyrazol-3-yl]-dimethylamine; [4(2-thoxynapthalen-1-ylmethyl)-5-ethyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylamine; [4(7-methoxyquinolin-8-ylmethyl)-5-methylsulfanyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylamine; 2-{1-[5-dimethlamino-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazol-4-ylmethyl]-napthalen-2-yloxy}-ethanol; enantiomeric [2-(2,6-dichloro-4-trifluoromethlphenyl)-5-ethyl-4-(3-methoxymethyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2H-pyrazol-3-yl]-dimethylamine derived from (+)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; and [4-(2-cyclopropylmethoxynapthalen-1-ylmethyl)-5-methylsulfanyl-2-(2,4,6-trichlorophenyl)-2H-pyrazol-3-yl]-dimethylamine.
 3. A method according to claim 1, wherein said compound is [5amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dimethylphenyl)methanone, [5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-bis-trifluoromethylphenyl)methanone, [5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(5-isopropyl-2-methylphenyl)methanone, [5-amino-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazol-4-yl]-(5-isopropyl-2-methylphenyl)methanone, or [5-amino-1-(4-bromo-2,6-dimethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dibromophenyl)methanone.
 4. A method according to claim 1, wherein said compound is [5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dimethylphenyl)methanone, [5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-bis-trifluoromethylphenyl)methanone, [5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(5-isopropyl-2-methyl phenyl)methanone, [5-amino-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolyl]-(5isopropyl-2-methylphenyl)methanone, or [5-amino-1-(4-bromo-2,6-dimethylphenyl)-3-methylsulfanyl-1H-pyrazol-4-yl]-(2,5-dibromophenyl)methanone.
 5. A method according to claim 1 wherein said compound is 3-{(4-methyl-benzyl)-[3,6-dimethyl-1-(2,4,6-trimethylphenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amino}-propan-1-ol; diethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine; 2-{butyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amino}-ethanol; dibutyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl}-amine; butyl-ethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine; butyl-ethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amine; butyl-cyclopropylmethyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine; di-1-propyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amine; diallyl-[6-methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine; butyl-ethyl-[6-chloro-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo [3,4-d]pyrimidin-4-yl]-amine; butyl-ethyl-[6-methoxy-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine; propyl-ethyl-[3,6-dimethyl-1-(2,4,6-trimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine; or 4-(1-ethyl-propyl)-6-methyl-3-methylsulfanyl-1-(2,4,6-trimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine.
 6. The method of claim 1, wherein said phobias are selected from the group consisting of agoraphobia, social phobia, and simple phobia.
 7. The method of claim 1, wherein said stress induced pain perception is fibromyalgia. 